Dr. Ugir's lab is conducting highly interdisciplinary research focused on pre-clinical development of dendrimer-drug conjugates against different disease, including cancer, which covers medicinal chemistry, nanotechnology based drug delivery, biological and animal studies. Dr. Ugir's current research interests include dendrimer-based targeted delivery of therapeutic drugs, in order to minimize toxicity and enhance the efficiency of treatment and imaging; synthesis of nanoconjugate, characterization and testing; preclinical in vitro and in vivo evaluation of anticancer therapeutics; sustained release characteristic of the drugs from nanodevices in physiological condition and determine pharmacokinetics. Recent goal is to develop single nanodevices of combination drugs therapy to increase efficacy against disease.
Publication: (total 34, Google Scholar Page) Selected Publications:
1. A R Patra, S. S Roy, A Basu, A Bhuniya, A Bhattacharjee, S Hajraa, U. H. Sk, R Baral, S Bhattacharya. Design and synthesis of coumarin-based organoselenium as a new hit for myeloprotection and synergistic therapeutic efficacy in adjuvant therapy. Scientific reports 8(1): 2194, 2018
2. V Patial, S Sharma and U H Sk*. Dendrimer conjugated estramustine nanocrystalline ‘DenDot’: An effective inhibitor of DMBA-TPA-induced papilloma formation in mouse. European Journal of Pharmaceutical Sciences (109, 316-323, 2017).
3. D N. Karelia, U H Sk, P Singh, A. S. P Gowda, M K. Pandey, S R Ramisetti, S Amin, A K Sharma, Discovery of a Dual Topoisomerase-IIα and Akt Pathway Inhibitor NISC-6 as Potential Melanoma Therapeutic. European Journal of Medicinal Chemistry, 2017, 135, 282-295.
4. U. H. Sk *, Nanosize dendrimers: potential use as carrier and antimicrobials, Antimicrobial Nanoarchitectonics, Editor: Alexandru Mihai Grumezecsu (ELSEVIER). 2017, Chapter 12, 323-355, Book Chapter; (Invited)
5. Kojima C, Sk U. H, Fukushima D, Irie K, Akazawa N, Umeda M, Niidome T. Effect of Main Chain Conformation to Thermosensitivity in Elastin-Like Peptide-Grafted Polylysine. RSC Advanced. 2015, 5, 104900-104906
6. U. H. Sk*, V. Patial, S. Sharma. Low toxic synthetic dendrimer conjugated podophyllotoxin nanodevice with potent antitumor activity against DMBA/TPA induced mouse skin carcinogenesis model. Toxicology Research. 2015, 4, 1204-1213. DOI: 10.1039/C5TX00112A
7. U. H. Sk, C. Kojima. Dendrimers for theranostic applications. BioMolecular Concepts. 2015, 6(3):205-17
8. D. Fukushima, U.H. Sk, Y. Sakamoto, I. Nakase, C Kojima Dual Stimuli-Sensitive Dendrimer: Photothermogenic Gold Nanoparticle-Loaded Thermo-Responsive Elastin-Mimetic Dendrimers. Colloids and Surfaces B: Biointerfaces. 2015, 132,155–160.
9. U. H. Sk, C. Kojima. Dendrimers for Drug Delivery of Anticancer Drugs. Frontiers in Clinical Drug n Research- Anti Cancer Agents, Bentham Science Publishers, Invited Article, Vol. 2, P3-25, 2015.
10. U. H Sk*, D. Dixit, E. Sen. Comparative study of microtubule inhibitors- Estramustine and natural Podophyllotoxin conjugated PAMAM dendrimer on glioma cell proliferation. Eur J Med Chem. 68, 47-57, August, 2013.
11. U. H. Sk, S. P. Kambhampati, M. K. Mishra, W. G. Lesniak, F. Zhang, R. M. Kannan. Enhancing the Efficacy of Ara-C through Conjugation with PAMAM Dendrimer and Linear PEG: A Comparative Study. Biomacromolecules. 14, 3, 801-810, February 2013.
12. J.K.Das, S. Sarkar, U. H. Sk, P. Chakraborty, R. K. Das, S. Bhattacharya. Diphenylmethyl selenocyanate attenuates malachite green induced oxidative injury through antioxidation and inhibition of DNA damage in mice. Indian J Med Res. 137, 1163-1173, June 2013.
13. Y. Cheng, U. H. Sk, Y. Zhang, X. Ren, L. Zhang, K. J. Huber-Keener, Y.-W. Sun, S. Amin,A. K. Sharma, J.-M. Yang. Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with promotion of both apoptotic and autophagic cell death, PloS One,7, 4, e35104, April, 2012.
14. U. H. Sk, A.S. P. Gowda, J. K. Yun, T. E. Spratt, S. Amin, A. K. Sharma, Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics, Eur J Med Chem., 46, 8, 3331-3338, August 2011.
15. J. A. Hengst, X. J. Wang, U. H. Sk, A. K. Sharma, S. Amin, J. K. Yun. Discovery and Evaluation of a Sphingosine Kinase 1 Specific Small molecule Inhibitor, Bioorg Med Chem Lett. 20, 24, 7498- 7502, Dec., 2010.
16. S. S. Roy, P. Ghosh, U. H. Sk, P. Chakraborty, J. Biswas, A. Bhattacharjee, S. Bhattacharya, Naphthalimide based novel organo selenocyanates: Finding less toxic forms of selenium that would retain protective efficacy, Bioorg Med Chem Lett. 20, 23, 6951-6955, Dec., 2010.
17. P. Chakraborty, S. S. Roy, U. H. Sk, S. Bhattacharya. Amelioration of cisplatin induced nephrotoxicity in mice by oral administration of diphenylmethyl selenocyanate, Free Radic Res., 45, 2,177-187, Feb. 2011.
18. P.S. Palkar, M. G. Borland, S. Naruhn, C. H. Ferry, C. Lee, U. H. Sk, A. K. Sharma, S. Amin, I. A. Murray, C. R. Anderson, G. H. Perdew, F. J. Gonzalez, R. Muller, J. M. Peters, PPARβ/δ-dependent and independent functions of the PPARβ/ δ agonist GSK3787. Mol Phermacol., 78, 419-430, 2010.
19. A. K. Sharma, U. H. Sk, P. He, J. Peters, S. Amin, Synthesis of isosteric selenium analog of the PPARβ/ δ- agonist GW501516 and comparison of biological activity, Bioorg Med Chem Lett., 20, 14, 4050-4052, July 2010.
20. A. K. Sharma, U. H. Sk, M. A. Gimbor, J. A. Hengst, X. Wang, J. Yun, S. Amin, Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated, EurJ Med Chem., 45, 9, 4149-4156, Sept., 2010.
21. U. H. Sk, A. K Sharma, S. Ghosh, S. Bhattacharya, Prevention of cadmium induced oxidative and hepatic damage in mice by a series of spiro [6-methoxytetralin-1, 3'-pyrrolidine] based organo selenocyanates: Effect of chain length, Eur J Med Chem., 45, 8, 3265-3273, August 2010.
22. P. Chackraborty, U. H. Sk, N. Murmu, J.K. Das, S. Pal, S. Bhattacharya, Modulation of Cyclophosphamide Induced Cellular Toxicity by Diphenylmethyl Selenocyanate In Vivo, an Enzymatic Study. J Cancer Mol., 4, 6, 183-189, 2009
23. P. Charaborty, U. H. Sk, S. Bhattacharya, Chemoprotection and enhancement of cancer chemotherapeutic efficacy of cyclophosphamide in mice bearing Ehrlich ascites carcinoma by diphenylmethyl selenocyanate. Cancer Chemother Pharmacol. 64, 5, 971-980, Oct. 2009.
24. A. Sarkar, P. Banerjee, U. H. Sk., S. Bhattacharya, S. C Bhattacharya, Role of hydrogen bonding on the spectroscopic properties of thiazolidinedione derivatives in homogeneous solvents. Spectrochim Acta A Mol Biomol Spectrosc., 72, 5, 1097-1102, June 2009.
25. R. Tewari, V. Sharma, N. Koul, A. Ghosh, C. Joseph, U. H. Sk, E. Sen., Ebselen abrogates TNFα induced pro-inflammatory response in glioblastoma. Mol Oncol., 3, 1, 77-83, Feb. 2009.
26. V. Sharma, R. Tewari, U. H. Sk, C. Joseph , E. Sen, Organoselenium Ebselen sensitizes glioblastoma cells to Tumor Necrosis factor (TNFα) induced apoptosis through two distinct pathways involving NF-ĸB downregulation and Fas-mediated formation of death inducing signaling complex, Int J Cancer., 123, 9, 2204-2212, Nov. 2008.
27. U. H. Sk.,S. Bhattacharya, Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes, Bioorg Med Chem Lett., 17, 5, 1149-1154, March, 2007.
28. R. K. Das, U. H. Sk.,S. Bhattacharya, Protective Effect of Diphenylmethyl selenocyanate against CCl4-induced hepatic injury, J Appl Toxicol., 27, 6, 527-537, Nov. 2007.
29. P. Banerjee, S. Chatterjee, S. Pramanik, U. H. Sk.,S. Bhattacharya, S. C, Bhattacharya, Spectroscopic studies of 2-(2-bromo-ethyl)-6-nitro-benzo[de]isoquinolene -1,3-dione in water/alkanol mixed solvents and nonionic micelle of Igepal CO series, Spectrochim Acta A Mol Biomol Spectrosc., 66, 4-5, 1110-1114, April, 2007.
30. S. Chatterjee, S. Pramanik, U. H. Sk.,S. Bhattacharya, S. C. Bhattacharya, Synthesis and Photoinduced intramolecular charge transfer of N-substituted1,8-Naphthalimide derivatives in homogeneous solvents and in presence of reduced glutathione. J Photochem Photobiol A Chem., 187, 1,64-71, March, 2007.
31. U. H. Sk, S. Bhattacharya, Prevention of cadmium induced lipid peroxidation, depletion of some antioxidative enzymes and glutathione by a series of novel organoselenocyanates, EnvironToxicol Pharmacol., 22, 3, 298-308, Nov., 2006.
32. U. H. Sk.,S. Sengupta, S. Bhattacharya, Synthesis and evaluation of antioxidative properties of a series of organoselenium compounds, Bioorg Med Chem., 13, 20, 5750-5758, Oct., 2005.
33. R. K. Das, U. H. Sk,S. Bhattacharya, Diphenylmethyl selenocyanate inhibits DMBAcroton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation Cancer Lett., 230, 1, 90-101, Dec. 2005.
34. S. K. Ghosh, U. H. Sk.,S. Bhattacharya, S. C. Bhattacharya, 2-(2-Selenocyanic acid ethyl ester)-1H-benz[de] isoquinoline-1,3-(2H)-dione, synthesis photophysics and interaction with bovine serum albumin: A spectroscopic approach J Photochem Photobiol B: Biol., 81, 2, 121-128, Nov. 2005.
