Dietetics & Nutrition Technology
Senior Scientist
Pharmacology
09417923132
15-04-1984
M. Pharm., Ph.D.

 

Research Area:

 

1. Currently in our laboratory we are working to validate the therapeutic potential of traditional medicinal herbs of Western Himalayan region, including elucidation of pharmacodymnamics of bioactive metabolites. Research is in progress to find out mTOR ligands of natural origin for neurological disorders.

 

2. Another reserch aspect involve development of food-based therapies for prophylaxis of chronic conditions.

 

Google Scholar (link): https://scholar.google.co.in/citations?user=TnKTCHUAAAAJ&hl=en

 

 

Major Projects

 

#

Funding Agency

Project Title

Role

Cost (Rs. in Lakhs)

Duration/ Status

1

SERB, DST, New    Delhi (Scheme: Early Research Award)

Development and evaluation of the molecular mechanism of Ketogenic diet for comprehensive management of epilepsy associated central and peripheral comorbidities in experimental animal models

PI

34.33752

2016-2019 (Completed)

2

CSIR, New Delhi

Phytopharma Mission

[Vertical D (VI): Phytopharmaceutical development of Cissampelos pareira as per RGs of AYUSH]

PI

52.95

2017-2020 (Completed)

3

CSIR, New Delhi

Nutraceuticals and Nutritionals Mission

 

a)  Development of nutraceutical for neurodegeneration linked cognitive impairments in elderly population (Work Package 4.2.)

Co-Nodal

 

 

PI

1830.54

 

 

74.20

2018-2020

 

-do-

4

BIRAC, DBT, New    Delhi

(Industry partner: Baijnath Pharmaceuticals)

Commercial scale production of tea catechin from green tea leaves, development of formulations as nutraceuticals and their human intervention studies

PI

147.41

(CSIR-IHBT Share)

2018-2021

(ongoing)

 

 

Awards

1. P.C. DANDIYA Award by INDIAN PHARMACOLOGICAL SOCIETY (2013).

2. Early Research Award by SERB, DST, New Delhi (2016).

3. Saroj V.N. Sharma by INDIAN PHARMACOLOGICAL SOCIETY at IPSCON-2017, Mumbai for best paper published in National or International journal in last 3 years on cardiovascular pharmacology the work is to carried out in Indian laboratory. Mahesh Gupta, Pallavi Sharma, Arindam G. Mazumder, Vikram Patial, Damanpreet Singh*. Nitric Oxide. 2015, 50: 105-113 (Received by Ms. Pallavi Sharma).

4. Dr. Hardyal Award by INDIAN PHARMACOLOGICAL SOCIETY at IPSCON-2017, Mumbai for best publication in the field of anti-inflammatory pharmacology. Arindam G. Mazumder, Pallavi Sharma, Vikram Patial, Damanpreet Singh*. Basic Clinical Pharmacology and Toxicology. 2017, 120:426-433 (Received by Mr. Arindam G. Mazumder).

5. Late Smt. Bimla Devi Memorial Best Paper award to Pallavi Sharma (Ph.D. student) for research paper “Pallavi Sharma, Supriya Sharma and Damanpreet Singh, Investigating the effect of 4’,5,7-Trihydroxyflavone in seizure-induced depression” at National Conference on "Chronic Ailments & Ayurveda" at Ayurvedic College Paprola (2017).

6. Second prize for the “BEST PRECLINICAL RESEARCH PAPER AWARD-2019” at National Workshop on Animal Pharmacology and Toxicology Studies (APTS-2019) by INDIAN PHARMACEUTICAL ASSOCIATION and Bapatla College of Pharmacy, Andhra Pradesh for paper Arindam G. Mazumder, Vikram Patial, Damanpreet Singh*. Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy. Brain, Behavior, and Immunity 2019, 75:84-93.

 

Visiting Scientist

    Visiting scientist under the New Southbound Partnership Program at National Research Institute of Chinese Medicine Taipei, Taiwan (2019).

 

 Membership of Professional Bodies/Organizations

1.    Life member of Indian Pharmacological Society

2.    Life member of Indian Academy of Neuroscience

3.    Life member of Indian Science Congress Association

4.    Registered with Punjab State Pharmacy Council

5.    External Examiner for several Indian Universities

6.    Grant evaluator for several government funding agencies

7.    Member Doctoral Advisory Committee (DAC) AcSIR, CSIR-IHBT

8.    Member Institutional Animal Ethics Committee (IAEC), CSIR-IHBT

9.    Member Institutional Ethics Committee (IEC), CSIR-IHBT

10. Member Board of Studies of the Chandigarh University

11. Member Selection Committee of CSIR-IHBT for appointment of research fellows.

 

Invited Talks/Articles

17. Zebrafish: A Preclinical Screening Platform in Drug Discovery in a Refresher Course on “Drug Discovers and Formulation Development” organized by UGC-Human Resource Development Centre, Jawaharlal Nehru Technological University, Hyderabad, Telangana (20/10/20).

16. Zebrafish: A Potential Tool for High-throughput Screening in Drug Discovery in an e-Faculty Development Program and International E-conference on Trends in Pharma Development, Technology & Practices (TPDTP 2020) organized by Chitkara University, Punjab in association with the Association of Pharmaceutical Teachers of India (APTI), (20/08/20).

15. Modeling Central Nervous System Disorders in Zebrafishas a resource personin AICTE sponsored online Short Term Training Program (STTP) on “Novel experimental techniques in preclinical research for CNS disorders” organized by S.K.B., College of Pharmacy, Kamptee, Nagpur University, Maharashtra (29/07/20)

14. Preclinical Research in Drug Development Using Zebrafish as an Experimental Model in a webinar on "Alternative to Animal Experimentation" organized by Chitkara University, Himachal Pradesh (27/07/20).

13. Traditional Herbs as a Source of Medicine in 2019 Joint Forum for Traditional Medicine under the New Southbound Policy-The Application and Translation of Traditional Medicine Resources at National Research Institute of Chinese Medicine, Taipei, Taiwan (22/10/19).

12. Agro-Technology of MAP and Commercially Important Medicinal Plants and Therapeutic Potential of Traditional Medicinal Herbs of Western Himalayas in a Refresher Training Course for Indian Forest Service (IFS) Officers on “Conservation and Development of Medicinal Plants and Benefit Sharing with Local Communities” at Himalayan Forest Research Institute (HFRI), Shimla (30/08/2019).

11. Zebrafish as an Experimental Model in Biomedical Research: Focus on Preclinical Epilepsy Research in IBRO-APRC MLSU School of Neuroscience, Mohanlal Sukhadia University, Udaipur India (2019).

10. Agro-Technology of MAP and Commercially Important Medicinal Plants and Therapeutic Potential of Traditional Medicinal Herbs of Western Himalayas in a Refresher Training Course for Indian Forest Service (IFS) Officers on “Conservation and Development of Medicinal Plants and Benefit Sharing with Local Communities” at Himalayan Forest Research Institute (HFRI), Shimla (2019).

9. Novel targets for management of epilepsy: Focus on therapeutic switching in 10th NIPER (R) Symposium on Nano Based Therapy for Neurodegenrative Diseases at NIPER, Raebareli (2018).

8. Natural products as potential therapeutic agents for comprehensive management of epilepsy in 8th NIPER (RBL)-CSIR-CDRI Symposium on Current Trends in Medicinal Chemistry & Pharmaceutical Sciences in Drug Discovery at NIPER, Raebareli (2016).

7. Alternative to Experimental Animals: Zebrafish as an Ideal Model in Faculty Development Program at Chandigarh University, Mohali (2015).

6. Quality, Safety and Regulatory Aspects in Food and Herbals in awareness seminar “Value Added Food Products” sponsored by Ministry of Micro Small and Medium Enterprises at CSIR-IHBT (2014).

5. Pharmacological Evaluation of Cardiovascular Drugs at GHG Khalsa College of Pharmacy, Ludhiana, Punjab (2013).

4. Pharmacological Evaluation of Centrally Acting Drugs at GHG Khalsa College of Pharmacy, Ludhiana, Punjab (2013).

3. Cardiovascular Drugs at Punjab College of Technical Education, Ludhiana, Punjab (2013).

2. Adverse Drug Reactions at Punjab College of Technical Education, Ludhiana, Punjab (2012).

1. Reviewer for several international journals including, British Journal of Pharmacology, Scientific Reports (Nature), Recent Patents on Biotechnology, Biomedicine & Pharmacotherapy, Food Research International, Journal of Applied Biomedicine, BMC Complementary and Alternative Medicine, Journal of Pharmaceutical Education and Research, Journal of Biomedical Materials Research: Part A., Nutritional Neuroscience, Pharmaceutical Biology and Journal of Intercultural Ethnopharmacology and many more. 

 

Selected Publications

 

Sharma, S., Sharma, M., Rana A.K., Joshi, R., Swarnkar, M.K., Acharya, V., Singh, D.* (2020). Deciphering key regulators involved in epilepsy-induced cardiac damage through whole transcriptome and proteome analysis in a rat model. Epilepsia (Accepted)

Sharma, P., Kumari, S., Sharma, J., Purohit, R, Singh, D.* (2020). Hesperidin interacts with CREB-BDNF signaling pathway to suppress pentylenetetrazole-induced convulsions in zebrafish. Frontiers in Pharmacology doi: 10.3389/fphar.2020.607797

 Devidas, S.B., Sendri, N., Rahmatkar, N.S., Singh, D., Bhandari, P. (2020).  Two undescribed diarylheptanoids from green husk of Carya illinoensis as acetylcholinesterase inhibitors. Natural Product Research doi: https://doi.org/10.1080/14786419.2020.1862833    

Kumari, S., Sharma, P., Mazumder, A.G., Rana, A.K., Sharma, S., Singh D*. (2020).  Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents. Journal of Neuroscience Methods doi: https://doi.org/10.1016/j.jneumeth.2020.108916

Rana A.K., Sharma, S., Singh, D.* (2020). Differential activation of Gsk-3β in the cortex and the hippocampus induces cognitive and behavioral impairments in middle-aged ovariectomized rat. Comprehensive Psychoneuroendocrinology doi: https://doi.org/10.1016/j.cpnec.2020.100019 

Rana, A. K., Rahmatkar S.N., Kumar, A., Singh, D*. (2020). Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Cytokine and Growth Factor Reviews doi: https://doi.org/10.1016/j.cytogfr.2020.08.002

Kaur, T., Singh, D., Singh, A.P., Pathak, D., Arora, S., Singh, B., Kaur, S., Singh, B. (2020). Stevioside protects against rhabdomyolysis-induced acute kidney injury through PPAR-γ agonism in rats. Drug Development Research doi: https://doi.org/10.1002/ddr.21722

Sharma, P., Sharma, S., Singh, D*., (2020) Apigenin reverses behavioral impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus. Nutritional Neuroscience 23: 118-127.

Fombang, E.N., Nobosssé, P., Mbofung, C.M.F., Singh, D., (2020) Optimising extraction of antioxidants from roasted Moringa oleifera Lam. leaves using response surface methodology. Journal of Food Processing and Preservation; 44:e14482 (I.F.: 1.288).

Sharma, P., Kumar, A., Singh, D*., (2019). Dietary flavonoids interaction with CREB-BDNF pathway: An unconventional approach for comprehensive management of epilepsy. Current Neuropharmacology 17: 1158-1175 

Mazumder, A.G., Kumari, S., Singh, D*., (2019). Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in Zebrafish. Epilepsy Research 157, 106207.

Kumari, S., Mazumder, A.G., Patial, V., Singh, D*., (2019). Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva. Prostaglandins, Leukotrienes and Essential Fatty Acids 143:15-20.

Tanwar, G., Mazumder, A.G., Bhardwaj, V., Kumari, S., Bharti, R., Yamini, Singh, D., Das, P., Purohit, R., (2019). Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures. Scientific Reports (Nature) 9: 7904 

Sharma, S., Mazumder, A.G., Rana, A.K., Patial, V., Singh, D*., (2019). Spontaneous recurrent seizures mediated cardiac dysfunction via mTOR pathway upregulation: A putative target for SUDEP management. CNS & Neurological Disorders-Drug Targets 18: 555-565.

Mazumder, A.G., Patial, V., Singh, D*., (2018). Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy. Brain, Behavior, and Immunity 75: 84-93.

Rana, A.K., Singh, D*., (2018). Targeting Glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management. Neuropharmacology 139:124-136.

Mazumder, A.G., Sharma, P., Patial, V., Singh, D*., (2017) Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation. Journal of Ethnopharmacology 204: 8-17.

Sharma S, Sharma P, Kulurkar P, Singh D, Kumar D, Patial V (2017). Iridoid glycosides fraction from Picrorhiza kurroa attenuates cyclophosphamide-induced renal toxicity and peripheral neuropathy via PPAR-γ mediated inhibition of inflammation and apoptosis. Phytomedicine 36: 108-117. 

Mazumder, A.G., Sharma, P., Patial, V., Singh, D*., (2017). Crocin attenuates kindling development and its associated cognitive impairments in mice via inhibiting reactive oxygen species-mediated NF-κB activation. Basic & Clinical Pharmacology & Toxicology 120: 426-433. 

Mazumder, A.G., Padwad, Y.S., Singh, D*., (2016). Anticancer mammalian target of rapamycin (mTOR) signaling pathway inhibitors: current status, challenges and future prospects in management of epilepsy. CNS & Neurological Disorders-Drug Targets 15: 945-955. 

Singh, P., Singh, D., Goel, R.K. (2016). Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: a repertoire of Glycyrrhiza glabra flavonoid antioxidants. Pharmaceutical Biology 54:1209-1218.

Singh, D., Goel, R.K. (2016). Anticonvulsant mechanism of saponins fraction from adventitious roots of Ficus religiosa L.: Possible modulation of GABAergic, calcium and sodium channel functions. Revista Brasileira de Farmacognosia 26: 579–585. 

Gupta, M., Pallavi, S., Mazumder, A.G. Patial, V., Singh, D*., (2015). Dwindling of cardio damaging effect of isoproterenol by Punica granatum L. peel extract involve activation of nitric oxide-mediated Nrf2/ARE signaling pathway and apoptosis inhibition. Nitric Oxide: Biology and Chemistry 50:105-113. 

Patial, V., Mahesh, S., Sharma, S., Partap, K., Singh, D., Padwad, Y.S. (2015). Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. Environmental Toxicology and Pharmacology 40: 445-452. 

Singh, D*. (2015). Neuropharmacological aspects of Crocus sativus L.: a review of preclinical studies and ongoing clinical research. CNS & Neurological Disorders-Drug Targets 14: 880-902. 

Singh, P., Singh, D., Goel, R.K. (2014). Ficus religiosa L. figs a potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities. Epilepsy and Behavior 41:171-178. 

Sharma, P., Sharma, S., Patial, V., Singh, D*., Padwad, Y.S. (2014). Zebrafish (Danio rerio): a potential model for nephroprotective drug screening. Clinical Queries: Nephrology 3: 97-105.   

Singh, D., Gawande, D., Singh, T., Poroikov, V., Goel, R.K. (2014). Revealing pharmacodynamics of medicinal plants using in silico approach: A case study with wet lab validation. Computers in Biology and Medicine 47: 1-6. 

Singh, D., Mishra, A., Goel, R.K. (2013). Effect of saponins fraction from Ficus religiosa on memory deficit, behavioral and biochemical impairments in pentylenetetrazol kindled mice. Epilepsy and Behavior 27: 206-211. 

Goel, R.K., Singh, D. (2013). Exploring selective serotonergic modulation involved in the anticonvulsant effect of Ficus religiosa fig extract. Indian Journal of Pharmacology 45: 537-538.  

Singh, B., Singh, D., Goel, R.K. (2012). Dual protective effect of Passiflora incarnata in epilepsy and its associated post-ictal depression. Journal of Ethnopharmacology 139: 273-279.

Singh, D., Singh, B., Goel, R.K. (2012). Role of saponins for the anticonvulsant effect of adventitious roots of Ficus religiosaPharmaceutical Biology 50: 816-822.

Goel, R.K., Singh, D., Lagunin, A., Poroikov, V. (2011). PASS-assisted exploration of new therapeutic potential of natural products. Medicinal Chemistry Research20: 1509-1514. 

Singh, D., Singh, B., Goel, R.K. (2011). Traditional uses, phytochemistry and pharmacology of Ficus religiosa: a review. Journal of Ethnopharmacology 134: 565-583. 

Singh, D., Singh, B., Goel, R.K. (2011). Hydroethanolic leaf extract of Ficus religiosa lacks anticonvulsant activity in acute electro-and chemo-convulsion mice models. Journal of Pharmaceutical Negative Results 2: 58-61. 

Singh, D., Goel, R.K. (2010). Proconvulsant potential of cyproheptadine in experimental animal models. Fundamental & Clinical Pharmacology 24: 451-455. 

Kaur, H., Singh, D., Singh, B., Goel, R.K. (2010). Anti-amnesic effect of Ficus religiosa in scopolamine-induced anterograde and retrograde amnesia. Pharmaceutical Biology 48: 234-240. 

Singh, D., Goel, R.K. (2009). Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways. Journal of Ethnopharmacology 123: 330-334.  

                                                                             (*): Corresponding author

 

Patent

1. Pralay Das, Yamini, Richa Bharti, Shankar Ram, Rituraj Purohit, Damanpreet Singh, Prince Anand, Yogendra S. Padwad (2019). Bioactive benzocycloheptane analogues from Himachalenes useful for the treatment of PI3K and MK2 related disorders (Indian Patent Application No.: 202011045582; Date of e-Filing: 19/10/2020).

 

Ph.D. Scholars

1.    Ms. Supriya Sharma (CSIR-SRF): Pre-submitted

2.    Ms. Pallavi Sharma (ICMR-SRF)

3.    Mr. Anil K. Rana (DST-INSPIRE-SRF)

4.  Mr Shubham N. Rahmatkar (GPAT-JRF)

5. Mr. Rajneesh Dhiman (CSIR-JRF)

6. Ms. Poonam Dhiman (CSIR-JRF)

      Ph.D. Awarded

1.    Dr. Arindam Ghosh Mazumder: Awarded (Present Position: Post doc fellow, Department of Pharmacology & Physiology, University of Rochester Medical Center, New York, USA.

 

Project Assistants

1.    Ms. Savita (CSIR Project Assistant-II)

2.    Mr. Amit Kumar (SERB-DST Project Fellow)

 

     CSIR-TWAS Fellow

1.    Mr. Pierre Nobosse (Ph.D. Awarded)

 

UGs and PGs Guided

A total of 25 UGs and PGs guided for dissertations/trainings

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