In-Vivo safety/toxicity evaluation
In-Vivo validation of medicinal herbs/drug molecules of Western Himalayan region for their hepato-protective, nephroprotective and wound healing potential
Supriya Sharma, Shalika Rana, Vikram Patial*, Mahesh Gupta, Shashi Bhushan Yogendra S Padwad (2016). Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice. Human and Experimental Toxicology, DOI: 10.1177/0960327115627689.
Shanka Walia, Supriya Sharma, Pankaj Markand Kulurkar, Vikram Patial*, Amitabha Acharya* (2016). A bimodal molecular imaging probe based on chitosan encapsulated magneto-fluorescent nanocomposite offers biocompatibility, visualization of specific cancer cells in vitro and lung tissues in vivo. International Journal of Pharmaceutics, 498:110-118.
Mahesh Gupta, Pallavi Sharma, Arindam G Mazumder, Vikram Patial, Damanpreet Singh (2015). Dwindling of cardio damaging effect of isoproterenol by Punica granatum L. peel extract involve activation of nitric oxide-mediated Nrf2/ARE signaling pathway and apoptosis inhibition. Nitric Oxide: Biology and Chemistry 50: 105-113.
Vikram Patial*, Mahesh S, Supriya Sharma, Kunal Pratap, Damanpreet Singh, Yogendra S. Padwad (2015). Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. Environmental Toxicology and Pharmacology. 40: 445â€“452. U
Ugir Hossain Sk, Vikram Patial, Supriya Sharma (2015). Low toxic synthetic dendrimer conjugated podophyllotoxin nanodevice with potent antitumor activity against DMBA/TPA induced mouse skin carcinogenesis model. Toxicology Research, 4:1204-1213.
Vikram Patial, RK Asrani, RD Patil, DR Leadaux and GE Rottinghaus (2013). Pathology of ochratoxin A-induced nephrotoxicity in japanese quail and its protection by seabuckthorn (Hippophae rhamnoides L.). Avian Diseases. 57(4):767-779.